Antibacterial activity of lomefloxacin in a pharmacokinetic in vitro model.
نویسندگان
چکیده
An in vitro model simulating two-compartment pharmacokinetics was used to study the antibacterial activity of lomefloxacin after single oral doses of 200 and 400 mg. Lomefloxacin produced reliable bactericidal activity against gram-negative aerobic bacteria and staphylococci. Bacterial strains for which MICs were less than 0.5 microgram/ml were inhibited with both dosing schedules. Doubling the dose from 200 to 400 mg increased the bactericidal activity only against Pseudomonas aeruginosa. Against Enterococcus faecalis lomefloxacin showed no effect. Selection of resistant variants during the simulation of treatment was observed with Staphylococcus aureus and P. aeruginosa.
منابع مشابه
Evaluation of γ-irradiation treatment on the antibacterial activities of Mentha piperita L. essential oils in vitro and in vivo systems (CLP inflammatory model)
Background: Mentha piperita L. essential oils have different antibacterial activity. In the present study, we investigated the effect of &gamma–irradiation on the antibacterial activities of Mentha piperita L. essential oils in vitro and in vivo systems. Materials and Methods: The aerial parts of peppermint were irradiated in a cobalt60 source with 0, 10 and 25 kGy absorbed doses. Then, t...
متن کاملEvaluation of Antibacterial Effects of Lecanora muralis SP. Extract on Staphylococcus Aureus and Salmonella Typhimurium in in-vitro and in animal model
Background & Objective: Staphylococcus aureus and Salmonella typhimurium are among important causes of infection and antibiotic resistance. It is essential to find antimicrobial compounds against them. The objective of this study is to evaluate the antibacterial activity of Lecanora muralis SP. extracts on Staphylococcus aureus and Salmonella typhimurium in in-vitro and in animal model.Ma...
متن کاملIn vitro Evaluation of the antibacterial activity of Platelet-rich Plasma against Selected Oral and Periodontal Pathogens
Background: Despite the availability of a wide range of antibiotics, bacterial infections are among important challenges for the healthcare system. Therefore, the introduction of new antimicrobial preparations such as platelet-rich plasma (PRP) could be suggested theoretically as a preventive measure for bacterial infections. We aimed to evaluate the in vitro antibacterial activity of PRP again...
متن کاملSynthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities
Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the 7 position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L2- oxo-2-(2- furyl) and N-[2- oxyimino (2- furyl) ethyl] piperazinyl quinolone derivatives...
متن کاملIn Vitro Antibacterial Activity of Rheum ribes Extract Obtained from Various Plant Parts Against Clinical Isolates of Gram-Negative Pathogens
Rheum ribes is among the Polygonaceae family which is endemic in Iran and a few neighboring countries. In this investigation, antibacterial effects of root, stalk and leaves extracts of Rheum ribes on a few common clinical isolates of gram negative pathogens were studied, using the cup plate and paper disc methods. Gram negative microorganisms studied were Escherichia coli, Klebsiella pneumonia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 34 6 شماره
صفحات -
تاریخ انتشار 1990